Drug Discovery & Development And The Profiles Behind It - Part I

In this exciting series, you will receive a look behind the scenes of drug discovery and development cycle and you will get to know the job profiles, actively involved in research, pre-clinical phase, clinical phase but also in the approval and market access and their important contribution.



Research and Development: Preclinical phase

Research and development is focused on the search for new drugs needed to develop new medicines. The research takes place mainly at universities but also within the pharmaceutical companies.

Chemical and biological research

Molecular biology plays an essential part in understanding the human body and the associated molecules to be treated, the so-called targets. Automated high-throughput screenings (HTS), ligand-based drug design or virtual screening are used to test which molecule or active substance from the substance libraries influences the target according to the classical key-lock principle.
If the researchers find so-called hits, they try to improve the binding capability and characteristics of the hits, so that a better binding to the target is guaranteed. In addition, the active substance should as far as possible respond to only one target and react on as few as possible to other molecules. Pharmaceutical researchers work for several years on the characteristics of one substance, which is tested for improvement in numerous laboratory tests.

Among others and not limited to, nemensis ag recruits and manages the following profiles in chemical and biological research:

  • Molecular Biologist
  • Cell Biologist
  • Chemist R&D (Chemistry and Biology)
  • Laboratory Technician / Assistant R&D (Chemistry and Biology)


Preclinical development

Before a drug candidate can be tested on humans, it must be examined by toxicologists on various aspects, such as whether the drug changes and influences the genetic material, giving rise to cancer etc. These studies take place in a test tube (in vitro) or using cell cultures, but some mechanisms of action must be tested on animals (in vivo), as required by law, because only drug candidates that have been tested on animals can be used for humans.
On completion of the preclinical phase, in average five years have passed.

Among others and not limited to, nemensis ag recruits and manages the following profiles in preclinical development:

  • Toxicologist
  • Zookeeper
  • Laboratory technician / Associate Scientist
  • Chemist / Scientist
  • Pharmacist
  • Quality Assurance Manager
  • Drug Safety Specialist
  • Investigator


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Pharmaindustrie massgebend bei der nationalen Forschung und Entwicklung [Blogeintrag]. (o.D.). Abgerufen 26. April, 2018, von http://www.interpharma.ch/fakten-statistiken/2095-der-weg-bis-zum-medikament-ist-lang
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